A queueing approach to multi-site enzyme kinetics

A queueing approach to multi-site enzyme kinetics.

Multi-site enzymes, defined as where multiple substrate molecules can bind simultaneously to the same enzyme molecule, play a key role in a number of biological networks, with the Escherichia coli protease ClpXP a well-studied example. These enzymes can form a low latency 'waiting line' of substrate to the enzyme's catalytic core, such that the enzyme molecule can continue to collect substrate ...

ENZYME KINETICS A Modern Approach

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Book review ENZYME KINETICS A Modern Approach

The Kinetics of Enzyme Mixtures

Even purified enzyme preparations are often heterogeneous. For example, preparations of aspartate aminotransferase or cytochrome oxidase can consist of several different forms of the enzyme.  For this reason we consider how different the kinetics of the reactions catalysed by a mixture of forms of an enzyme must be to provide some indication of the characteristics of the species present.  Based...

A queueing approach to a multi class M/G/1 make-to-stock with backlog